{"id":3738,"date":"2025-06-05T13:26:12","date_gmt":"2025-06-05T05:26:12","guid":{"rendered":"https:\/\/www.mymab.com.cn\/?p=3738"},"modified":"2025-06-05T13:33:14","modified_gmt":"2025-06-05T05:33:14","slug":"how-tissue-microarrays-facilitate-tumour-microenvironment-tme-research","status":"publish","type":"post","link":"https:\/\/www.mymab.com.cn\/zh\/how-tissue-microarrays-facilitate-tumour-microenvironment-tme-research\/","title":{"rendered":"\u7ec4\u7ec7\u5fae\u9635\u5217\uff08TMA\uff09\u5982\u4f55\u63a8\u52a8\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7814\u7a76"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"3738\" class=\"elementor elementor-3738\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c303b6 e-flex e-con-boxed e-con e-parent\" data-id=\"5c303b6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e2b3e4e elementor-widget elementor-widget-heading\" data-id=\"e2b3e4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">\u7ec4\u7ec7\u5fae\u9635\u5217\uff08TMA\uff09\u5982\u4f55\u63a8\u52a8\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7814\u7a76<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-21ab215 elementor-widget elementor-widget-heading\" data-id=\"21ab215\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4ec0\u4e48\u662f\u80bf\u7624\u5fae\u73af\u5883\uff1f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5420c8b elementor-widget elementor-widget-text-editor\" data-id=\"5420c8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u80bf\u7624\u5fae\u73af\u5883\uff08Tumour Microenvironment\uff0cTME\uff09\u662f\u80bf\u7624\u5468\u56f4\u590d\u6742\u7684\u751f\u6001\u7cfb\u7edf\uff0c\u5b83\u652f\u6301\u764c\u7ec6\u80de\u7684\u751f\u957f\u4e0e\u53d1\u5c55\u3002TME\u7531\u80bf\u7624\u7ec6\u80de\u3001\u5468\u56f4\u7684\u8840\u7ba1\u3001\u5404\u79cd\u514d\u75ab\u7ec6\u80de\u4ee5\u53ca\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u7ec4\u6210\u3002\u8fd9\u4e9b\u5143\u7d20\u901a\u8fc7\u7ec6\u80de\u95f4\u63a5\u89e6\u3001\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u7b49\u53ef\u6eb6\u6027\u4ecb\u8d28\u6216\u5176\u4ed6\u673a\u5236\u4e0e\u80bf\u7624\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u5f71\u54cd\u80bf\u7624\u7684\u751f\u957f\u3001\u53d1\u80b2\u4e0e\u8f6c\u79fb\u3002<\/p><p>TME\u7684\u6bcf\u4e2a\u7ec4\u6210\u90e8\u5206\u90fd\u5728\u80bf\u7624\u8fdb\u5c55\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\u3002\u5916\u6ccc\u4f53\u3001\u51cb\u4ea1\u5c0f\u4f53\u7b49\u4ecb\u8d28\u4e5f\u53c2\u4e0e\u8c03\u63a7\u80bf\u7624\u884c\u4e3a\u7684\u4fe1\u53f7\u7f51\u7edc\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-67eae01 e-flex e-con-boxed e-con e-parent\" data-id=\"67eae01\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-559ebb7 elementor-widget elementor-widget-heading\" data-id=\"559ebb7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4e3a\u4ec0\u4e48\u80bf\u7624\u5fae\u73af\u5883\u7814\u7a76\u5982\u6b64\u91cd\u8981\uff1f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3554a60 elementor-widget elementor-widget-text-editor\" data-id=\"3554a60\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>TME\u7814\u7a76\u662f\u63a8\u52a8\u80bf\u7624\u5b66\u8fdb\u6b65\u7684\u5173\u952e\u3002\u901a\u8fc7\u6df1\u5165\u4e86\u89e3TME\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u53d1\u73b0\u80bf\u7624\u53d1\u5c55\u7684\u65b0\u673a\u5236\uff0c\u5e76\u786e\u5b9a\u521b\u65b0\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u4ece\u800c\u6539\u5584\u60a3\u8005\u8bca\u65ad\u548c\u9884\u540e\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4f7a128 e-flex e-con-boxed e-con e-parent\" data-id=\"4f7a128\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4250b9f elementor-widget elementor-widget-heading\" data-id=\"4250b9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u4e86\u89e3\u80bf\u7624\u751f\u7269\u5b66<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55e99a1 elementor-widget elementor-widget-text-editor\" data-id=\"55e99a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>\u80bf\u7624\u8fdb\u5c55\u673a\u5236<\/strong>\uff1a\u80bf\u7624\u7ec6\u80de\u4f9d\u8d56\u5176\u5468\u56f4\u73af\u5883\u6765\u8c03\u63a7\u5176\u884c\u4e3a\u4e0e\u5b58\u6d3b\u3002\u5bf9TME\u7684\u7814\u7a76\u6709\u52a9\u4e8e\u63ed\u793a\u80bf\u7624\u7684\u53d1\u751f\u4e0e\u53d1\u5c55\u673a\u5236\u3002<\/li><li><strong>\u52a8\u6001\u5f02\u8d28\u6027<\/strong>\uff1aTME\u9ad8\u5ea6\u52a8\u6001\uff0c\u4f1a\u968f\u7740\u80bf\u7624\u7684\u53d1\u5c55\u53d1\u751f\u53d8\u5316\u3002\u5176\u7ec4\u6210\u53d6\u51b3\u4e8e\u80bf\u7624\u7684\u6765\u6e90\u3001\u5185\u5728\u7279\u5f81\u4ee5\u53ca\u60a3\u8005\u4e2a\u4f53\u5dee\u5f02\uff0c\u56e0\u6b64\u7814\u7a76\u5176\u5404\u7ec4\u6210\u6210\u5206\u81f3\u5173\u91cd\u8981\u3002<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8d17a7c e-flex e-con-boxed e-con e-parent\" data-id=\"8d17a7c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1843d52 elementor-widget elementor-widget-heading\" data-id=\"1843d52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u63a8\u52a8\u764c\u75c7\u6cbb\u7597\u53d1\u5c55<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f2e1f3 elementor-widget elementor-widget-text-editor\" data-id=\"0f2e1f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>\u9776\u5411\u6cbb\u7597<\/strong>\uff1aTME\u4e2d\u5305\u542b\u4fc3\u80bf\u7624\u548c\u6297\u80bf\u7624\u5206\u5b50\u3002\u4e86\u89e3\u8fd9\u4e9b\u5206\u5b50\u6709\u52a9\u4e8e\u7814\u53d1\u80fd\u591f\u6291\u5236\u80bf\u7624\u53d1\u5c55\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6848\u3002<\/li><li><strong>\u63d0\u5347\u6cbb\u7597\u6548\u679c<\/strong>\uff1aTME\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u5e38\u5e38\u6210\u4e3a\u6709\u6548\u8f93\u9001\u836f\u7269\u7684\u969c\u788d\uff0c\u964d\u4f4e\u6cbb\u7597\u6548\u679c\u3002\u901a\u8fc7TME\u5206\u6790\u53ef\u4ee5\u4f18\u5316\u836f\u7269\u9012\u9001\u7b56\u7565\u3002<\/li><li><strong>\u589e\u5f3a\u514d\u75ab\u6cbb\u7597<\/strong>\uff1aTME\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u5df2\u6210\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597 (Immunotherapy) \u7684\u91cd\u8981\u9776\u70b9\u3002\u7814\u7a76TME\u4e2d\u7684\u514d\u75ab\u53cd\u5e94\u80fd\u591f\u63d0\u5347\u514d\u75ab\u7597\u6cd5\u7684\u6548\u679c\u3002<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9fb511d e-flex e-con-boxed e-con e-parent\" data-id=\"9fb511d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-565cc04 elementor-widget elementor-widget-heading\" data-id=\"565cc04\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7ec4\u7ec7\u5fae\u9635\u5217\uff08TMA\uff09\u5728TME\u7814\u7a76\u4e2d\u7684\u4f5c\u7528<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a11f4ed elementor-widget elementor-widget-text-editor\" data-id=\"a11f4ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u7ec4\u7ec7\u5fae\u9635\u5217\uff08Tissue Microarrays, TMAs\uff09\u662f\u4e00\u79cd\u9ad8\u901a\u91cf\u6280\u672f\uff0c\u5df2\u5728\u764c\u75c7\u7814\u7a76\u4e2d\uff0c\u5c24\u5176\u662f\u5728\u80bf\u7624\u5fae\u73af\u5883\u7814\u7a76\u4e2d\u53d1\u6325\u4e86\u53d8\u9769\u6027\u4f5c\u7528\u3002\u5176\u8d21\u732e\u5982\u4e0b\uff1a<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-52c68a1 e-flex e-con-boxed e-con e-parent\" data-id=\"52c68a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-14ecc4f elementor-widget elementor-widget-heading\" data-id=\"14ecc4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">1. \u751f\u7269\u6807\u5fd7\u7269 (Biomarker) \u53d1\u73b0<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45a7720 elementor-widget elementor-widget-text-editor\" data-id=\"45a7720\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u901a\u8fc7\u540c\u65f6\u5206\u6790\u591a\u4e2a\u7ec4\u7ec7\u6837\u672c\uff0cTMA\u53ef\u7528\u4e8e\u8bc6\u522b\u4e34\u5e8a\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u7ed3\u5408\u591a\u91cd\u67d3\u8272\u6280\u672f\uff0cTMA\u53ef\u4ee5\u63ed\u793a\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u751f\u7269\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u6a21\u5f0f\uff0c\u63a8\u52a8\u521b\u65b0\u6cbb\u7597\u65b9\u6848\u7684\u53d1\u73b0\uff0c\u540c\u65f6\u4e5f\u4e3a\u4e2a\u4f53\u5316\u533b\u7597\u63d0\u4f9b\u65b0\u65b9\u5411\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6742cb3 elementor-widget elementor-widget-heading\" data-id=\"6742cb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">2. \u514d\u75ab\u7279\u5f81\u5206\u6790<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1930760 elementor-widget elementor-widget-text-editor\" data-id=\"1930760\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u514d\u75ab\u7ec4\u5316\uff08Immunohistochemistry, IHC\uff09\u548c\u514d\u75ab\u8367\u5149 (Immunofluorescence, IF)\u662f\u514d\u75ab\u80bf\u7624\u5b66\u7684\u91cd\u8981\u5de5\u5177\u3002TMA\u80fd\u591f\u8ba9\u7814\u7a76\u4eba\u5458\u5206\u6790\u5927\u89c4\u6a21\u6837\u672c\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u60c5\u51b5\uff0c\u6709\u52a9\u4e8e\u7406\u89e3\u80bf\u7624\u7684\u5f02\u8d28\u6027\u3001\u514d\u75ab\u6291\u5236\u72b6\u6001\u4ee5\u53ca\u75be\u75c5\u9884\u540e\u3002\u901a\u8fc7TMA\u8fdb\u884c\u514d\u75ab\u7279\u5f81\u5206\u6790\u8fd8\u53ef\u4ee5\u9884\u6d4b\u6cbb\u7597\u53cd\u5e94\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-490d4ac elementor-widget elementor-widget-heading\" data-id=\"490d4ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">3. \u80bf\u7624\u5fae\u73af\u5883\u5206\u6790<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div 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data-id=\"55dc9e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">4. \u6cbb\u7597\u53cd\u5e94\u9884\u6d4b<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff8aa43 elementor-widget elementor-widget-text-editor\" data-id=\"ff8aa43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div 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The tumour microenvironment (TME) is a complex ecosystem surrounding a tumour that supports cancer cell growth and progression. It is composed of tumour cells, stromal cells, diverse immune cells, and the extracellular matrix (ECM). 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